CLINICAL TRIALS AND OBSERVATIONS Lenalidomide, bortezomib, pegylated liposomal doxorubicin, and dexamethasone in newly diagnosed multiple myeloma: a phase 1/2 Multiple Myeloma Research Consortium trial
نویسندگان
چکیده
Andrzej J. Jakubowiak,1 Kent A. Griffith,1 Donna E. Reece,2 Craig C. Hofmeister,3 Sagar Lonial,4 Todd M. Zimmerman,4 Erica L. Campagnaro,5 Robert L. Schlossman,6 Jacob P. Laubach,6 Noopur S. Raje,7 Tara Anderson,1 Melissa A. Mietzel,1 Colleen K. Harvey,1 Sandra M. Wear,8 Jennifer C. Barrickman,9 Craig L. Tendler,10 Dixie-Lee Esseltine,11 Susan L. Kelley,8 Mark S. Kaminski,1 Kenneth C. Anderson,6 and Paul G. Richardson6
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
We report the results of a phase 2 trial using lenalidomide plus dexamethasone (Rev/ Dex) as initial therapy for myeloma. Thirtyfour patients were enrolled. Lenalidomide was given orally 25 mg daily on days 1 to 21 of a 28-day cycle. Dexamethasone was given orally 40 mg daily on days 1 to 4, 9 to 12, and 17 to 20 of each cycle. Objective response was defined as a decrease in serum monoclonal pr...
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This trial determined the safety and efficacy of the combination regimen clarithromycin (Biaxin), lenalidomide (Revlimid), and dexamethasone (BiRD) as first-line therapy for multiple myeloma. Patients received BiRD in 28-day cycles. Dexamethasone (40 mg) was given orally once weekly, clarithromycin (500 mg) was given orally twice daily, and lenalidomide (25 mg) was given orally daily on days 1 ...
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1Division of Hematology, Mayo Clinic, Rochester, MN; 2Sarah Cannon Research Institute, Nashville, TN; 3Department of Medical Oncology Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA; 4Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI; 5Bone Marrow/Hematology Clinics, University of Wisconsin Comprehensive Cancer Center, Madison, WI; 6Sinai Hospit...
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This prospective study evaluated the risk of arterial thrombosis in 195 consecutive patients aged 18 to 65 years with newly diagnosed multiple myeloma (MM). All patients were treated with 3 cycles of VAD (vincristine, doxorubicin, and dexamethasone) or TAD (thalidomide-AD) or PAD (bortezomib-AD) in national trials, followed by high-dose melphalan and autologous stem cell transplantation. For a ...
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